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Polymer genomics: an insight into pharmacology and toxicology of nanomedicines

As discussed earlier, viral infection stimulates the activity of NADPH oxidase, which produces superoxide using NADPH as an electron donor in the cell

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Furthermore, they discovered that in connection with oxidative pentose phosphate, pre-incubating cells with methionine enhanced cellular tolerance to the thiol-oxidizing agent diamide

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Among the metals for which this mechanism has been demonstrated are: zinc [157], cadmium [149,158,159], mercury [160,161], manganese [159,161,162,163], cobalt [164], nickel [165]