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In 67% of patients even complete normalisation of alkaline phosphatase was observed, which is more rarely obtained with FXR ligands (7% with OCA)96 or budesonide (35%).71 Importantly, pruritus, liver stiffness and prognostic scores of PBC improved, in line with other recent studies confirming the positive effects on pruritus145 146 and long-term outcomes from the vast Japanese experience.147 Side effects include increases in serum creatinine, myalgia and hepatotoxicity (ALT elevations)

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Interaction Between Astrocytes and Neurons Studied Using a Mathematical Model of Compartmentalized Energy Metabolism. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 25: 14761490

This also requires further testing of the genetically engineered EcN (Traise et al., 2024) to determine its efficacy in vivo

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Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1(+/-) mouse model of autism spectrum disorders