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However, the weight loss achieved with a 0.5 mg dose (9.2%) was only slightly lower than that of a 1 mg dose (10.6%)

This is because B12 plays a vital role in the production of red blood cells, which are responsible for transporting oxygen throughout the body

As posited by Qichun Zhang et al., the administration of BBR prior to the onset of treatment led to the activation of endogenous neuroprotective mechanisms associated with the sphingosine-1-phosphate (S1P)/HIF-1 pathway, thereby contributing to the protection of neuronal cells from the deleterious effects of hypoxia/ischemia (Zhang et al., 2016a)

doi: 10.1111/j.1478-4408.2003.tb00188.x