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Another factor has been neglect of this area by pharmaceutical companies

doi: 10.1002/eji.200939889 78 FanC-SChenCCChenLLChuaKVHungHCHsuJTet al

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a 7-NI: 7-nitro-indazole, BBB: bloodbrain barrier, CNS: central nervous system, DA: dopamine, Gol-NO: golgi-targeted fluorescent probe, iNOS: inducible NOS, IL-6: interleukin-6, LID: L-DOPA-induced dyskinesia, nNOS: neuronal NOS, NO: Nitric oxide, NOS: NO synthase, PD: Parkinsons Disease, TNF-: tumor necrosis factor , -syn: -synuclein

Despite an initially sensitive chemotherapy, most ovarian cancers relapse with chemoresistance, which is featured by genotypic alteration and metabolic changes