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Ca 2+ is not metabolized and an overload of mitochondrial Ca 2+ may break down the electrochemical proton gradient resulting in a deficit of ATP followed by necrosis [89]

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Ferroptosis is characterized by the accumulation of lipid peroxides and is regulated by enzymes such as glutathione peroxidase 4 (GPX4) and the system Xc- antiporter

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This article is educational and not medical advice

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doi: 10.1016/S0969-806X(98)00155-8

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Recommendations for blood pressure targets in diabetes range from less than 130/80 mm Hg to less than 140/90 mm Hg

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If cardiovascular symptoms develop or worsen, reduce or withhold the liothyronine sodium dose for one week and restart at a lower dose

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