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The development of highly selective or isoform-specific inhibitors will reduce side effects and is an important goal for the near future

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Kolarikova M, Hosikova B, Dilenko H, BartonTomankova K, Valkova L, Bajgar R, et al

3.2.2 Hepatic processing and distribution of gut-derived metabolites The liver, as the body's largest metabolic organ, possesses robust capabilities for substrate extraction and biotransformation