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10.1016/j.jconrel.2023.11.030 63 HuaL.LeiT.QianH.ZhangY.HuY.LeiP

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148 In addition to instigating the XBP1s-mediated transcriptional response, activated IRE1 also serves as a scaffolding protein that facilitates the activation of other signaling pathways

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Unfortunately, pain scores were not assessed at any earlier points in this study, it is therefore unknown whether pain had decreased more in the B12 group at an earlier time point