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Marked mitotic activity and geographic tumor necrosis are also commonly present [3]

DAMPs such as HMGB1 and S100A8/A9 secreted by adipocytes bind to RAGE, promoting macrophage polarization toward the M1 phenotype and releasing proinflammatory cytokines, thereby exacerbating systemic low-grade inflammation 56,163

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The collagen stimulation process begins within a couple of weeks, becomes noticeable after two to three months, and reaches its peak around the three- to six-month mark