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The study looked at whether a combination of cardiovascular outcomes (heart attack, stroke, cardiac death, mini-stroke, urgent heart surgery for coronary disease) were more common in the allopurinol or the febuxostat group
This results in impaired B12 absorption, due to an inability to properly isolate B12

doi: 10.1038/mt.2010.311

doi:10.1093/aje/kwg166
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