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Experimental data suggest that microbes such as p ks (polyketide synthase)+ Escherichia coli (pks+Ec), ETBF , Fn , and SGG , damage the gut-barrier lining and colonocyte DNA, increase proinflammatory cytokines and oxidative factors, and produce potentially carcinogenic toxins (17, 24, 5861)

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IRS-1 is an adaptor protein that provides a binding site for PI-3 kinase, whose activation stimulates Akt ( Figure 2 )

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