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increased rates of epithelial cell proliferation, as measured by bromodeoxyuridine (BrdU) incorporation

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These cells can arise from various sources, including the transdifferentiation of resident fibroblasts (fibroblast-to-myofibroblast transition, FMT), epithelial cells (epithelial-to-mesenchymal transition, EMT), or endothelial cells (endothelial-to-mesenchymal transition, EndMT) [86]