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doi: 10.1183/13993003.02197-2017 154 GanPXLZhangSFred WongWS

In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation ( TP53, encoded by the TP53 gene and mutated in over 50% of human cancers, is essential for cell-cycle regulation and the induction of programmed cell death

Indirect hyperbilirubinemia typically results from increased red blood cell turnover, increased bilirubin loading, or disturbances in hepatocellular update and bilirubin conjugation

Notably, NRF2 shows a bidirectional ability in regulating ferroptosis, whereby a decreased expression can stimulate the sensitivity of cancer cells to ferroptosis, while an increased level inhibits the ferroptosis process [86, 87]

PMID 10059978

Frommann, C