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117 Combined, these factors can lead to nutrient deficiency, which can impair immune function and lower the body's resistance to infection

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The immune reaction to disease depends on fast replication of cells, which itself depends on adequate availability of B12 and folate

Notably, non-synonymous mutations such as p.Ala373Ser, p.Ser398Thr, and p.Thr725Pro in the TPO gene, along with p.Ser508Leu and p.Glu727Asp in TSHR gene, were detected in these patients

Ferroptosis is an iron-dependent controlled cell death caused by polyunsaturated fatty acid-containing phospholipids (PL-PUFA) in cell membranes that differentiates from other types of cell death by iron-dependent accumulation of lipid peroxides and redox imbalance (3)

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