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Compared with T2DM patients with healthy periodontal conditions, T2DM patients with periodontitis exhibit significantly higher expression of ferroptosis-related genes, such as IL-1, IL-6, NFE2L2, and ALOX5, in pancreatic tissue [158]

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Typical cerebral metabolic patterns in neurodegenerative brain diseases

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Patients homozygous for I278T often retain residual enzyme activity and respond to B6 therapy, whereas the G307S mutation, common in Irish and Australian populations, is associated with a severe phenotype and non-responsiveness to B6 (2426)

Gtp cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling