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The subject also experienced other inflammatory phenomena during this time, including swollen joints and rosacea, although his hsCRP remained below 3 mg/L

Additionally, clinical evidence suggests that high-dose vitamin C (2 g orally, achieving ~5080 M plasma levels) can effectively restore endothelial function in inflammatory and age-related vascular conditions by enhancing NO bioavailability and reducing oxidative stress, even without significantly altering systemic inflammatory markers, like IL-6 or C-reactive protein [89]

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To further validate that Slc25A4 interacts with Ozz in vivo, we immunoprecipitated mitochondrial lysates from gastrocnemius and soleus muscles using anti-Slc25A4 antibodies and probed the blots with an anti-Ozz antibody (Fig