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Blood 129(18):2584-2587, 2017

SGLT2 inhibitors such as dapagliflozin and canagliflozin target the glycolytic enzyme PFKFB3, promoting a shift from M1 to M2 polarization through metabolic reprogramming and thereby ameliorating steatosis and fibrosis in non-alcoholic fatty liver disease (176)

14 The involvement of the MCL and other knee ligaments in similar reflex arcs suggests that the ligamento-muscular system is a comprehensive, multi-ligament network designed to provide synergistic stabilization across multiple planes of motion

Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes

The higher tissue glutamate level supports both the glutamatergic neurotransmission and also GABA resynthesis and other processes such as e.g

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