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Additionally, hypomethylation of the BIN1 gene at specific CpGs (26, 44, and 87) in the blood has been associated with an increased risk of LOAD (Salcedo-Tacuma et al., 2019), while hypermethylation of the PIN1 gene promoter distinguished frontotemporal dementia (FTD) from the hypomethylation observed in AD ( APP and BACE1 , reduced DNMT1, and upregulated DNMT3a and DNMT3b, thereby alleviating AD-like symptoms (Pi et al., 2022)

The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response

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