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Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells

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Next, to investigate whether the induction of inflammatory cytokines from RAW264.7 cells occurs in response to CRP itself or via modulation of other molecules by CRP, we challenged RAW264.7 cells with recombinant CRP or CM-CRP

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Plaque Formation Processes Plaque forms when lipids, inflammatory cells, and smooth muscle cells gather in arteries