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Gold nanoparticles targeting the autophagy-lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: from mechanism to therapy

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Cellular distribution of the GSH/GSSG couple The GSH/GSSG couple is the principal redox buffer of a cell owing to its high concentration compared with other redox couples (88)

This suggests that in microglia with an anti-inflammatory phenotype, there is limited MGO formation and/or efficient MGO detoxification

6.2 Potential toxicity to normal cells While biogenic AgNPs are recognized for their potent cytotoxic effects against cancer cells, it is crucial to thoroughly evaluate their potential toxicity to normal cells to ensure their safe application in clinical settings

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