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Neuromuscular preparation (sciatic nerve - gastrocnemius muscle in situ) the method for studying the muscle response is based on that described by Charlton MP et al

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performed the high-throughput screening based on the library of Bayer compounds, and found that 2-amino-3-cyano-4-aryl-6-(2-hydroxy-phenyl)pyridine analogue ( 68 , Figure 17 ) displayed a potent inhibitory activity against IKK (IC 50 = 1500 nM) [180]
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Targeting ferroptosis: Paving new roads for drug design and discovery
