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NPs derived from natural sources have the ability to capture free radicals by several processes, such as chelation of metal ions, enzyme inhibition and direct scavenging of ROS

This means that upon unfolding due to stresses, supercharged variants can refold and exhibit significant activity even in cases where the unmodified protein cannot 27

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Elevated excretion of p -cresol sulfate was accompanied by a reduced production of N-acetylcysteinyl conjugates of acetaminophen suggesting an impaired ability to detoxify APAP reactive metabolites

To counter ROS-mediated stress and reduce the overall tissue damage, cells possess diverse defense mechanisms