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Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets

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Figure 4 4 Therapeutic strategies targeting ferroptosis in Alzheimers disease 4.1 Therapeutic strategies targeting iron homeostasis In AD, the disruption of iron homeostasis is considered a pivotal upstream event that triggers ferroptosis activation and drives pathological spread (Figure 5)

However, if antioxidant defense systems are severely impaired or the more realistic scenario that an iron supplement is co-ingested, the mode of cell death can be switched to ferroptosis