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Broadly, the toxins your liver has to process fall into three groups: Environmental toxins: pesticides, heavy metals and air pollutants

Cell Mol Life Sci 57:18251835 Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J, Lackner KJ, AtheroGene Investigators (2003) Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease

This has led some researchers to target 9mg rather than 12mg as their maintenance dose, especially given that the difference (2.3 percentage points) may not justify the additional side effect burden for all individuals

Hofman et al., 1996

Misra et al., 2024[91]