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This has become especially problematic due to the increasing emphasis on the diagnosis of very early melanoma
The role of CXCL9 and CXCL10 chemokines in vitiligo has been defined to induce cytotoxic T cell production and migration to the basal layer of the epidermis, where they target melanocytes, cause their apoptosis, and decrease melanin production [68]

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References: Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Brger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Khnen P, Kobilka BK, Scheerer P

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