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Description
The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+

Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure

When selenium is low, this conversion gets less efficient and you can end up with hypothyroid-like symptoms even when your thyroid is otherwise working normally

PMID 15514282

However, the drugs antiglycation properties are not well known

This tissue type has rich blood flow that allows steady, controlled absorption into your bloodstream over several days
