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CNS Drugs

Natural compounds such as 1-methyl-l, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ), resveratrol, curcumin, and gingko biloba have garnered considerable inhibition owing to their ability to scavenge excess free radicals to protect neurons

In this setting, TGF1 is probably the primary pro-fibrogenic factor in the formation of fibrotic plaques ( in vitro ( On the other hand, it is reported that TGF1 is a possible driver of Rho-associated coiled-coil protein kinase (ROCK) ( Fibrotic conditions often involve an imbalance between deposition and degradation of ECM in the proliferation and remodeling phase

doi: 10.1016/j.drugalcdep.2008.03.014

However, the dose of polyphenols alone is not a crucial factor when considering the toxic potential of phenolic compounds, as it also depends on the time of exposure and possible synergistic effects

The use of Generalized Linear Mixed Models in the study has allowed for more comprehensive data analysis, considering additional covariates and their potential interactions throughout the treatment