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According to the National Heart, Lung, and Blood Institute, this absorption failure makes B12 injections the primary and most effective treatment, as they deliver the nutrient directly where your body can use it, bypassing the digestive system entirely

Additionally, SubQ injections are generally less painful

This is also true for people who cant absorb nutrients well

Moreover, comparative investigations often help laboratories establish consistent evaluation standards across multiple projects

For severe cases, the first dose is usually 1,000 mcg given intramuscularly every day or every other day for a week or two

Up to 60% of people have a version of this mutation leading to a decreased ability to absorb B12