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Only the study of Cavallini et al

Regulation of the Mitochondrial Acetyl-CoA/CoA Ratio and Acyl-CoA/CoA Ratio l-carnitine has a key role in the regulation of acyl-CoA and acetyl-CoA, and in the preservation of free CoA levels within the mitochondria, which is crucial for maintaining metabolic flexibility

It is synthesised naturally from the amino acids lysine and methionine, primarily in the liver and kidneys, though it can also be obtained through dietary sources such as red meat and dairy products