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Overexposure to tin may damage the nervous system and cause psychomotor disturbances including tremor, convulsions, hallucinations, and psychotic behavior

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1Simon A., Wegrowski Y., Bontemps Y., Maquart F.X. Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complexglycyl-L-histidyl-L-lysine-Cu( 2+ )J. Investig. Dermatol.2000;115:962968. doi:10.1046/j.1523-1747.2000.00166.x

The primary underlying pathomechanism is most likely a decreased hepatic GHR expression related to insulin deficiency, resulting in GH-resistance and impaired hepatic IGF-1 synthesis, which stimulates pituitary GH-secretion by a feedback mechanism [188, 189]