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Depurinating estrogen-DNA adducts, generators of cancer initiation: Their minimization leads to cancer prevention

Nature 276, 515517

Changes in stress-mediated markers in a human cardiomyocyte cell line under hyperglycemia
Transfer 25 nL compound to 384 assay plate by Echo 655

Animals were pretreated (1 hr beforestress) with saline (controls) or BPC 157 (dissolved insaline) (10 g or 10 ng/kg body wt intraperitoneallyor intragastrically) applied either alone to establishbasal conditions or, when manipulating the adrenergic or dopaminergic system, a simultaneousadministration was carried out with various agents withspecific effects on adrenergic or dopaminergic receptors[given in milligrams per kilogram intraperitoneally except for atenolol, which was givensubcutaneously] phentolamine (10.0), prazosin (0.5),yohimbine (5.0), clonidine (0.1) (-adrenergicdomain), propranolol (1.0), atenolol (20.0)(-adrenergic domain), domperidone (5.0), and haloperidol(5.0) (peripheral/central dopamine system).Alternatively, agents stimulating adrenergic ordopaminergic systemsadrenaline (5.0) or bromocriptine(10.0)-were applied

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