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246 Another observational study in 35 fibromyalgia patients found that adding a combination of micronized and ultra-micronized PEA to treatment with duloxetine plus pregabalin for three months was associated with further reductions in tender points and pain

Key points to consider when interpreting the evidence: Most studies are short-term , typically lasting fewer than 12 weeks, making it difficult to assess long-term efficacy or safety Results appear more pronounced in older adults or individuals with obesity, compared to younger, healthy populations L-carnitine alone, without dietary or lifestyle changes , is unlikely to produce clinically meaningful weight loss Neither NICE nor the NHS recommends L-carnitine supplementation as part of any weight management pathway

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Estimating the mean and variance from the median, range, and the size of a sample

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Theyre also one of the best recovery supplements for runners as they may reduce muscle soreness and speed up recovery