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It's so well-established that researchers regularly use it as the go-to benchmark when testing new brightening ingredients

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doi: 10.1016/j.simyco.2018.06.001

IKK activity is triggered during aging by NF-B (Kim et al., 2002), which further modulates the p38 MAPK, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinases (JNKs) pathways that modulate the NF-B-dependent transcriptional activity during the inflammatory reaction