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Cardiac ketone body metabolism

BBB is a biological and physical barrier consisting of astrocytes, pericytes, and brain microvascular endothelial cells (BMECs) that maintains the dynamic between the peripheral circulation and the central nervous system (21)

Any excess is typically excreted in the urine, lowering the risk of toxicity

Combating oxidative stress in the brain potentially aids in preventing and managing neurodegenerative diseases

However, much of this literature is limited by small sample sizes, observational designs, heterogeneous phase definitions, and incomplete control of diet, physical activity, and ovulation verification, which constrains causal inference

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