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Natarajan A, Zlitni S, Brooks EF, Vance SE, Dahlen A, Hedlin H, et al

Additionally, many of the currently available clinical agents display the always on characteristic, where they illuminate disease sites through self-accumulation rather than being specifically activated by target molecules of interest, which leads to poor imaging contrast and compromised detection accuracy

Using a clean and stable environment for administration

They suffer specifically from insulin deficiency in the hepatic portal circulation as a result of the subcutaneous delivery of insulin (reviewed by Dunger (64))

By systematically reviewing and synthesizing existing literature, this article aims to provide insights for further investigation into ferroptosis mechanisms in OA and to broaden potential therapeutic targets and approaches for clinical management of ferroptosis-related pathological processes
