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In a study using A53T mice, a high-calorie diet exacerbated autonomic dysfunction that occurs in early disease stages in these animals

V.Pinheiro-JuniorE

SRG/2022/001285)

The correlation analyses further revealed a positive relationship between fat mass, body fat percentage, and IL-6 ( = 0.42 and = 0.45, respectively), suggesting that greater adiposity may contribute to low-grade systemic inflammation

291,292 The activation of inflammation leads to cell damage, and eventually, the accumulation of damage accelerates aging
