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As the immune system battles perceived threats, it generates high levels of reactive oxygen species (ROS)

G6PD-deficient cells are unable to generate enough NADPH under the condition of severe thiol depletion and GSH biosynthesis and methionine cycle are upregulated at the expense of ATP but fail to compensate for GSH depletion (311)

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Interestingly, RSL3 did not suppress p70S6K protein levels in HThF cells to the extent observed in K1 cells (Fig

The results of the in silico assay supported these effects

exploratory analysis in the Lothian birth cohort 1936