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Comparing the efficacy of radiolabeled daratumumab in MM patients, 225 Ac-based therapy showed superior tumor growth delay and reduced systemic toxicity compared to 177 Lu-based therapy [133]
Although the serum MMA concentration reflects an intracellular cobalamin deficiency, other causes of elevated MMA must be considered, such as renal failure, reduced plasma volume reduction, and abnormalities in hepatic methyl-malonyl CoA mutase activity [15,47]

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