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Wang N, Wang W, Liu C, et al

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Meanwhile, 6 kinds of alkaloids (palmatine, columbamine, jatrorrhizine, tetrahydropalmatine, and romaine) were speculated to play significant roles in the prevention of AD progression

Tubulin glutamylation and its enzymatic machinery Tubulin glutamylation is a reversible PTM that fine-tunes MT functions, and its dynamic nature is governed by the coordinated actions of two opposing enzyme families: the writers and the erasers. The writers are the tubulin tyrosine ligase-like (TTLL) glutamylases [23], which add glutamate residues to the CTTs of - and -tubulin, whereas the erasers are the cytosolic carboxypeptidases (CCPs), which remove these side chains [24, 25]

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With this perspective, Daughaday et al.[5, 42] proposed the somatomedin hypothesis for the postnatal growth, where GH stimulated skeletal growth by stimulating liver production of IGF-I, which in turn promotes longitudinal bone growth in an endocrine manner