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Low B12 levels may be helped by increased intake through your diet, an oral or sublingual supplement, or sometimes even B12 injections

The membrane pellet was resuspended in buffer (20 mM Tris pH 8.0, 150 mM NaCl) and homogenized with the help of a Dounce homogenizer, followed by the addition of 30 mM n-dodecyl--D-maltopyranoside (DDM) and 6 mM cholesteryl hemisuccinate (CHS) for solubilization at 4 C

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In fact, low B12 levels can cause discolouration of nails, brittle hair, dry lips and mouth and even hyperpigmentation