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Chronic treatment with AOD 9604 in obese mice produced significant weight reduction and changes in fat pad weight

Severe vomiting or diarrhea can lead to loss of fluids (dehydration) which may cause kidney problems to become worse

[PubMed abstract]

Our novel NNMT inhibitors display excellent physical chemical properties (e.g., membrane permeability), selectivity, and cellular inhibitory activity against NNMT, concomitantly enhancing the levels of the cofactors SAM and NAD + that independently regulate cellular energy metabolism and epigenetic modifications
