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Unresolved inflammation results in formation of vulnerable plaques characterized by enhanced macrophage apoptosis and defective efferocytosis of apoptotic cells resulting in necrotic cell death leading to increased smooth muscle cell death, decreased extracellular matrix production, and collagen degradation by macrophage proteases

doi: 10.3389/fphar.2025.1629803

19, 21 Other members of the TMEM16 family, that include 16C, 16D, 16F, 16G, and 16J have been shown to scramble PS, although it awaits clarification in which cell types, and by what activation signals, these scramblases function

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The functioning of the peripheral clock is regulated by signals from autonomic innervation (from the central clock), endocrine networks, feeding, and other external cues