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Treatment with NG52, a PDHK1 inhibitor, blocked glycolysis and led to ROS accumulation, thereby suppressing the CD4 + T cell and Th17 cell responses in patients with myocarditis [106]
During viral vector cell culture production, empty capsids lacking genetic material are also generated and represent a key product-related impurity due to potential off-target immune responses (Wright, 2014
Wang, D., Wang, C., Wu, H., Li, Z
Jian-Kang Chen, pathologist and kidney researcher in the MCG Department of Cellular Biology and Anatomy, measured T cell infiltration in the chronic models
I 2 = 0%)
Sweeney et al., 2018)
