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A phase 1, randomized, double-blind, placebo-controlled, crossover study to evaluate the pharmacodynamic effects of VX-150, a highly selective Na V 1.8 inhibitor, in healthy male adults

G., Zanardi, R., Palladini, M., Rovere-Querini, P

[6] Zhao P, Zhang B, Gao S

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However, this reaction proceeds at a slow rate (0.02 times/sec) and, thus, it would take around 50 seconds for any single G-protein to deactivate if other factors did not come into play