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The A2B receptor has also been studied in a model of lung fibrosis caused by bleomycin, where it seems to have different roles during both the acute and the chronic stages of lung injury [136]

C., Wu, Z., Geng, Y., & Moshage, H

Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression

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Once methionine and SAM levels are restored, SCF Met30 binding to Met4 is promoted resulting in its ubiquitylation and return to a stable, but transcriptionally inactive state