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It catalyzes the rate-limiting step in the catabolism of the prooxidant heme to carbon monoxide, biliverdin, and free iron [85]

In the UK, the increasing popularity of plant-based diets has heightened awareness of this risk, with the Vegan Society recommending regular B12 supplementation

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Thus, if old red cells have much less G6PD activity than reticulocytes in G6PD normal blood, the oldest red cells in G6PD-deficient blood will have nearly zero activity