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So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen bacterial fragments, undigested food particles, pathogens cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load

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doi: 10.1093/jn/nxab309

Astrocytes are the main regulators of extracellular glutamate concentration through the GLT-1 and GLAST glutamate transporters