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Because the pro-invasive action of P-cadherin is unlikely to be the result of alterations in cell-cell adhesion, we presumed that the pro-invasive activity of P-cadherin was due to changes in cytoplasmic signalling pathways, as was described for E-cadherin

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Trimming of the papillae may be required in extreme cases (20)

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Patients with tumors that are larger than 5 cm have an estimated 32-fold higher risk of developing metastases compared with patients who have tumors smaller than 5 cm