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Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Villikka K, Kivist KT, Neuvonen PJ
Recommendations for future clinical trials The initial oral dose for the clinical trial patient treatment group should be set at 5 mg/kg every 12 h, with the potential for appropriate increases based on the absence of peripheral neuropathy and the patient's ability to tolerate at least 6.25 mg/kg per hour

The muscle often feels noticeably looser and range of motion improves right away
