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Fibrinogen promotes atherosclerosis by increasing inflammation, inducing expression of immune cell adhesion molecules on blood vessel surfaces, and stimulating vascular smooth muscle cell migration and proliferation

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The plasma levels of PGE2, 8-iso-PGE2, PGA2, and 8-iso-PGA2, which are involved in the initiation of inflammation and in the regulation of immune responses [39], were higher in CRP-overexpressing mice (Fig
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