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3.1.1 Chronic Obstructive Pulmonary Disease COPD is a major worldwide health problem that is increasing in prevalence and mortality (Rennard and Drummond, 2015)

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The interaction of GR with GRE causes additional conformational changes to take place in the receptor which facilitates the recruitment of, and interaction with, transcriptional coregulators that assist the transcriptional regulatory actions of the GR

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